Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease.

ABSTRACT: Patients with sickle cell disease (SCD) are at high risk of developing serious infections, therefore, understanding the impact that severe acute respiratory syndrome coronavirus 2 infection has on this population is important. We sought to identify factors associated with hospitalization and serious COVID-19 illness in children and adults with SCD.We established the international SECURE-SCD Registry to collect data on patients with SCD and COVID-19 illness. We used multivariable logistic models to estimate the independent effects of age, sex, genotype, hydroxyurea, and SCD-related and -nonrelated comorbidities on hospitalization, serious COVID-19 illness, and pain as a presenting symptom during COVID-19 illness. As of 23 March 2021, 750 COVID-19 illness cases in patients with SCD were repo

SUBMITTER: Mucalo L 

PROVIDER: S-EPMC8248962 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature