P3H4 Overexpression Serves as a Prognostic Factor in Lung Adenocarcinoma.

ABSTRACT:

Background

The present study is aimed at evaluating the functional and clinical values of P3H4 in lung adenocarcinoma. Moreover, we also investigated the downstream pathways that P3H4 might participate in.

Methods

The differential expression analysis was used to identify genes differentially expressed in lung adenocarcinoma tissues as compared with normal tissues. Survival analysis was used to test the association between P3H4 and survival time. Gene set enrichment analysis was conducted to explore the downstream pathways. CCK8 and transwell were employed to examine the impact of P3H4 on cell phenotypes.

Results

P3H4 was highly upregulated in LUAD tissues at both RNA and protein levels. Moreover, the LUAD patients, who had high expression of P3H4, were also observed t

SUBMITTER: Jin X 

PROVIDER: S-EPMC8249155 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature