Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers.

ABSTRACT:

Background

Pentraxin 3 (PTX3) influences innate immunity and inflammation, host defence, the complement cascade and angiogenesis. PTX3 expression in lung and blood of subjects with tobacco exposure, and its potential relationship with disease pattern and clinical outcome are poorly understood.

Methods

Using independent platforms and cohorts, we identified associations of PTX3 gene expression in lung tissue and plasma from current and former tobacco smokers (with and without chronic obstructive pulmonary disease, COPD) to disease phenotypes including quantitative CT determined emphysema, lung function, symptoms and survival. Two putative regulatory variants of the PTX3 gene were examined for association with COPD manifestations. The relationship between plasma PTX3 and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8249179 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature