Improvements in clinical signs of Parkinson's disease using photobiomodulation: a prospective proof-of-concept study.

ABSTRACT:

Background

Parkinson's disease (PD) is a progressive neurodegenerative disease with no cure and few treatment options. Its incidence is increasing due to aging populations, longer disease duration and potentially as a COVID-19 sequela. Photobiomodulation (PBM) has been successfully used in animal models to reduce the signs of PD and to protect dopaminergic neurons.

Objective

To assess the effectiveness of PBM to mitigate clinical signs of PD in a prospective proof-of-concept study, using a combination of transcranial and remote treatment, in order to inform on best practice for a larger randomized placebo-controlled trial (RCT).

Methods

Twelve participants with idiopathic PD were recruited. Six were randomly chosen to begin 12 weeks of transcranial, intranasal, neck a

SUBMITTER: Liebert A 

PROVIDER: S-EPMC8249215 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature