Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.

ABSTRACT:

Objectives

To evaluate the possibility of predicting the risk of progression from mild cognitive impairment (MCI) to dementia using a combination of clinical/demographic parameters.

Methods

A total of 462 MCI elderly patients (follow-up: 33 months). Variable measured included cognitive functions, age, gender, MCI type, education, comorbidities, clinical chemistry, and functional status.

Results

Amnestic type (aMCI) represented 63% of the sample, non-amnestic (naMCI) 37%; 190 subjects progressed to dementia, 49% among aMCI, and 28% among naMCI. At Cox multivariate regression analysis, only MMSE (one point increase HR 0.84; 95% CI 0.79-0.90), aMCI (HR 2.35; 95% CI 1.39-3.98), and age (1 year increase HR 1.05; 95% CI 1.01-1.10) were independently associated with progress

SUBMITTER: Zuliani G 

PROVIDER: S-EPMC8249246 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature