Luminal Breast Cancer: Risk of Recurrence and Tumor-Associated Immune Suppression.

ABSTRACT: Hormone-receptor positive (HR+) breast cancer (BC) (including the luminal A and the luminal B subtypes) is the most common type of tumor in women diagnosed with early-stage BC (EBC). It represents a highly heterogeneous subgroup that is characterized by different risks of relapse. The aim of this review is to discuss the possible role played by the immune response in predicting this risk, along with the most common clinical and pathological factors and molecular tools that have been developed and are already in use. As opposed to what has previously been observed in the most aggressive human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancer (TNBC) subtypes, a high proportion of tumor-infiltrating lymphocytes (TILs)-reflecting a spontaneous and pre-existin

SUBMITTER: Pellegrino B 

PROVIDER: S-EPMC8249273 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature