Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation.
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ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC8249405 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation.
Sun He H Zhu Xinlu X Li Chuanxi C Ma Zhiming Z Han Xiao X Luo Yuanyuan Y Yang Liang L Yu Jing J Miao Yansong Y
Nature communications 20210701 1
The intrinsically disordered region (IDR) is a preserved signature of phytobacterial type III effectors (T3Es). The T3E IDR is thought to mediate unfolding during translocation into the host cell and to avoid host defense by sequence diversification. Here, we demonstrate a mechanism of host subversion via the T3E IDR. We report that the Xanthomonas campestris T3E XopR undergoes liquid-liquid phase separation (LLPS) via multivalent IDR-mediated interactions that hijack the Arabidopsis actin cytos ...[more]
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