A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease.

ABSTRACT: There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson's disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater understanding of the risk factors that contribute to modify disease course is of clear importance for optimizing patient care and clinical trial design. Genetic variants in SNCA are an established risk factor for PD and are candidates to modify disease presentation and progression. This systematic review aimed to summarize all available primary research reporting the association of SNCA polymorphisms with features of PD. We systematically searched PubMed and Web of Science, from inception to 1 June 2020, for studies evaluating the association of common SNCA variants with age at

SUBMITTER: Pedersen CC 

PROVIDER: S-EPMC8249472 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature