Acute toxicity and antimalarial studies of extract of  Allophylus spicatus in animals.

ABSTRACT: Medicinal plants produce a variety of chemical substances with varied physiological effects. They are a huge reservoir of various chemical substances with potential therapeutic properties. Allophylus spicatus is a shrub that belong to  the Sapindaceae family. In this study, male  albino wistar rats (18) were used for acute toxicity test. Animals were divided into six groups of three rats each. Group A served as the control group while the other groups were dosed orally with 200, 500, 1000, 2000 and 5000 mg/kg body weight of extract and were observed for 14 days. Swiss albino mice (42) were used for the antimalarial study; five groups of six infected mice per group (Groups C-G) were respectively dosed orally with 25 mg chloroquine/kg bw, 200 mg of extract/kg bw, 400 mg/kg bw of extra

SUBMITTER: Adebayo AH 

PROVIDER: S-EPMC8249555 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature