Ontology highlight
ABSTRACT:
SUBMITTER: Tarke A
PROVIDER: S-EPMC8249675 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Tarke Alison A Sidney John J Methot Nils N Yu Esther Dawen ED Zhang Yun Y Dan Jennifer M JM Goodwin Benjamin B Rubiro Paul P Sutherland Aaron A Wang Eric E Frazier April A Ramirez Sydney I SI Rawlings Stephen A SA Smith Davey M DM da Silva Antunes Ricardo R Peters Bjoern B Scheuermann Richard H RH Weiskopf Daniela D Crotty Shane S Grifoni Alba A Sette Alessandro A
Cell reports. Medicine 20210702 7
The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of addressing whether the total CD4<sup>+</sup> and CD8<sup>+</sup> T cell recognition is also affected. Here, we compare SARS-CoV-2-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells against the B.1.1.7, B.1.351, P.1, and CAL.20C lineages in COVID-19 convalescents and in recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines. The total reactivity against SARS-CoV-2 var ...[more]