Probiotics ameliorate alveolar bone loss by regulating gut microbiota.

ABSTRACT:

Objectives

Oestrogen deficiency is an aetiological factor of postmenopausal osteoporosis (PMO), which not only decreases bone density in vertebrae and long bone but also aggravates inflammatory alveolar bone loss. Recent evidence has suggested the critical role of gut microbiota in osteoimmunology and its influence on bone metabolisms. The present study aimed to evaluate the therapeutic effects of probiotics on alveolar bone loss under oestrogen-deficient condition.

Materials and methods

Inflammatory alveolar bone loss was established in ovariectomized (OVX) rats, and rats were daily intragastrically administered with probiotics until sacrifice. Gut microbiota composition, intestinal permeability, systemic immune status and alveolar bone loss were assessed to reveal the unde

SUBMITTER: Jia L 

PROVIDER: S-EPMC8249787 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature