Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress.

ABSTRACT:

Objectives

The area of the subventricular zone (SVZ) in the adult brain exhibits the highest number of proliferative cells, which, together with the olfactory bulb (OB), maintains constant brain plasticity through the generation, migration and integration of newly born neurons. Despite Tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. in Alzheimer's disease (AD)], it remains unknown whether Tau plays a role in the neurogenic process of the SVZ and OB system under conditions of chronic stress, a well-known sculptor of brain and risk factor for AD.

Materials and methods

Different types of newly born cells in SVZ and OB were analysed in animals that lack Tau gene (Tau-KO) and th

SUBMITTER: Dioli C 

PROVIDER: S-EPMC8249793 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature