Delayed access to conscious processing in multiple sclerosis: Reduced cortical activation and impaired structural connectivity.

ABSTRACT: Although multiple sclerosis (MS) is frequently accompanied by visuo-cognitive impairment, especially functional brain mechanisms underlying this impairment are still not well understood. Consequently, we used a functional MRI (fMRI) backward masking task to study visual information processing stratifying unconscious and conscious in MS. Specifically, 30 persons with MS (pwMS) and 34 healthy controls (HC) were shown target stimuli followed by a mask presented 8-150 ms later and had to compare the target to a reference stimulus. Retinal integrity (via optical coherence tomography), optic tract integrity (visual evoked potential; VEP) and whole brain structural connectivity (probabilistic tractography) were assessed as complementary structural brain integrity markers. On a psychophysical leve

SUBMITTER: Has Silemek AC 

PROVIDER: S-EPMC8249884 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature