Functional connectivity of the human hypothalamus during wakefulness and nonrapid eye movement sleep.

ABSTRACT: Animal experiments indicate that the hypothalamus plays an essential role in regulating the sleep-wake cycle. A recent neuroimaging study conducted under resting wakefulness conditions suggested the presence of a wake-promoting region and a sleep-promoting region in the human posterior hypothalamus and anterior hypothalamus, respectively, and interpreted their anticorrelated organization in resting-state functional networks as evidence for their opposing roles in sleep-wake regulation. However, whether and how the functional networks of the two hypothalamic regions reorganize according to their wake- or sleep-promoting roles during sleep are unclear. Here, we constructed functional networks of the posterior and anterior hypothalamus during wakefulness and nonrapid eye movement (NREM) sleep

SUBMITTER: Jiang J 

PROVIDER: S-EPMC8249893 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature