Abnormal prediction error processing in schizophrenia and depression.

ABSTRACT: To make adaptive decisions under uncertainty, individuals need to actively monitor the discrepancy between expected outcomes and actual outcomes, known as prediction errors. Reward-based learning deficits have been shown in both depression and schizophrenia patients. For this study, we compiled studies that investigated prediction error processing in depression and schizophrenia patients and performed a series of meta-analyses. In both groups, positive t-maps of prediction error tend to yield striatum activity across studies. The analysis of negative t-maps of prediction error revealed two large clusters within the right superior and inferior frontal lobes in schizophrenia and the medial prefrontal cortex and bilateral insula in depression. The concordant posterior cingulate activity was o

SUBMITTER: Yaple ZA 

PROVIDER: S-EPMC8249895 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature