Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems.

ABSTRACT: Pancreatic β-cells are a critical cell type in the pathology of diabetes. Models of genetic syndromes featuring diabetes can provide novel mechanistic insights into regulation of β-cells in the context of disease. We previously examined β-cell mass in models of two ciliopathies, Alström Syndrome (AS) and Bardet-Biedl Syndrome (BBS), which are similar in the presence of metabolic phenotypes, including obesity, but exhibit strikingly different rates of diabetes. Zebrafish models of these disorders show deficient β-cells with diabetes in AS models and an increased β-cells absent diabetes in BBS models, indicating β-cell generation or maintenance that correlates with disease prevalence. Using transcriptome analyses, differential expression of several exocrine pancreas proteases with directiona

SUBMITTER: Hostelley TL 

PROVIDER: S-EPMC8249909 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature