Dataset Information

Age and Education Effects on a Novel Syntactic Assessment Battery for Elderly Adults.

ABSTRACT: The purpose of this study was to delineate the properties of a novel syntactic assessment battery and to present descriptive data on normal elderly individuals. We administered the Syntactic Assessment Battery (hereinafter SAB) using a sentence-picture paradigm to 195 normal elderly adults in three age groups (60-69, 70-79, and 80-90) and five educational levels (No formal education, Elementary School Graduation, Middle School Graduation, High School Graduation, College Graduation and Above). A multiple linear regression model was applied to verify the age and education effects. A summary of results indicated that the SAB effectively detected age and education effects. People generally demonstrated worse performance as they aged but better performance as their educational levels increased. People with high school education and above generally demonstrated stronger performance on the test, although educational effects were not significantly different between elementary and middle school graduation groups. The current novel syntactic assessment battery can serve as a screening measure that sensitively detects age and education effects.

SUBMITTER: Sung JE

PROVIDER: S-EPMC8249940 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Age and Education Effects on a Novel Syntactic Assessment Battery for Elderly Adults.

Sung Jee Eun JE Ahn Heekyung H Choi Sujin S Lee Kiseop K

Frontiers in psychology 20210618

The purpose of this study was to delineate the properties of a novel syntactic assessment battery and to present descriptive data on normal elderly individuals. We administered the Syntactic Assessment Battery (hereinafter SAB) using a sentence-picture paradigm to 195 normal elderly adults in three age groups (60-69, 70-79, and 80-90) and five educational levels (No formal education, Elementary School Graduation, Middle School Graduation, High School Graduation, College Graduation and Above). A ...[more]

PMID: 34220611

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Project description:BackgroundWe recently reported that CSF phosphorylated tau (p-Tau181) relative to Aβ40 (CSF p-Tau/Aβ40 ratio) was less noisy and increased associations with Alzheimer's disease (AD) biomarkers compared to CSF p-Tau181 alone. While elevations of CSF p-Tau/Aβ40 can occur in amyloid-β (Aβ) negative (Aβ-) individuals, the factors associated with these elevations and their role in neurodegeneration and cognitive decline are unknown. We aim to explore factors associated with elevated tau in CSF, and how these elevated tau are related to neurodegeneration and cognitive decline in the absence of Aβ positivity.MethodsWe examined relationships between CSF p-Tau/Aβ40, and CSF Aβ42/Aβ40, Aβ PET, and white matter hyperintensities (WMH) as well as vascular risk factors in 149 cognitively unimpaired and 52 impaired individuals who were presumably not on the Alzheimer's disease (AD) pathway due to negative Aβ status on both CSF and PET. Subgroups had 18F-fluorodeoxyglucose (FDG) PET and adjusted hippocampal volume (aHCV), and longitudinal measures of CSF, aHCV, FDG PET, and cognition data, so we examined CSF p-Tau/Aβ40 associations with these measures as well.ResultsElevated CSF p-Tau/Aβ40 was associated with older age, male sex, greater WMH, and hypertension as well as a pattern of hippocampal atrophy and temporoparietal hypometabolism characteristic of AD. Lower CSF Aβ42/Aβ40, higher WMH, and hypertension but not age, sex, Aβ PET, APOE-ε4 status, body mass index, smoking, and hyperlipidemia at baseline predicted CSF p-Tau/Aβ40 increases over approximately 5 years of follow-up. The relationship between CSF p-Tau/Aβ40 and subsequent cognitive decline was partially or fully explained by neurodegenerative measurements.ConclusionsThese data provide surprising clues as to the etiology and significance of tau pathology in the absence of Aβ. It seems likely that, in addition to age, both cerebrovascular disease and subthreshold levels of Aβ are related to this tau accumulation. Crucially, this phenotype of CSF tau elevation in amyloid-negative individuals share features with AD such as a pattern of metabolic decline and regional brain atrophy.

Dataset Information

Age and Education Effects on a Novel Syntactic Assessment Battery for Elderly Adults.

Publications

Age and Education Effects on a Novel Syntactic Assessment Battery for Elderly Adults.

Similar Datasets

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