Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors.

ABSTRACT: Prion diseases have been described in humans and other mammals, including sheep, goats, cattle, and deer. Since mice, hamsters, and cats are susceptible to prion infection, they are often used to study the mechanisms of prion infection and conversion. Mammals, such as horses and dogs, however, do not naturally contract the disease and are resistant to infection, while others, like rabbits, have exhibited low susceptibility. Infection involves the conversion of the cellular prion protein (PrP^C) to the scrapie form (PrP^Sc), and several cofactors have already been identified as important adjuvants in this process, such as glycosaminoglycans (GAGs), lipids, and nucleic acids. The molecular mechanisms that determine transmissibility between species remain unclear, as well

SUBMITTER: Angelli JN 

PROVIDER: S-EPMC8249948 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature