Interindividual immunogenic variants: Susceptibility to coronavirus, respiratory syncytial virus and influenza virus.

ABSTRACT: The coronavirus disease (Covid-19) pandemic is the most serious event of the year 2020, causing considerable global morbidity and mortality. The goal of this review is to provide a comprehensive summary of reported associations between inter-individual immunogenic variants and disease susceptibility or symptoms caused by the coronavirus strains severe acute respiratory syndrome-associated coronavirus, severe acute respiratory syndrome-associated coronavirus-2, and two of the main respiratory viruses, respiratory syncytial virus and influenza virus. The results suggest that the genetic background of the host could affect the levels of proinflammatory and anti-inflammatory cytokines and might modulate the progression of Covid-19 in affected patients. Notably, genetic variations in innate imm

SUBMITTER: Darbeheshti F 

PROVIDER: S-EPMC8250219 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature