Bleeding risk by intensity of anticoagulation in critically ill patients with COVID-19: A retrospective cohort study.

ABSTRACT:

Background

Studies report hypercoagulability in coronavirus disease 2019 (COVID-19), leading many institutions to escalate anticoagulation intensity for thrombosis prophylaxis.

Objective

To determine the bleeding risk with various intensities of anticoagulation in critically ill patients with COVID-19 compared with other respiratory viral illnesses (ORVI).

Patients/methods

This retrospective cohort study compared the incidence of major bleeding in patients admitted to an intensive care unit (ICU) within a single health system with COVID-19 versus ORVI. In the COVID-19 cohort, we assessed the effect of anticoagulation intensity received on ICU admission on bleeding risk. We performed a secondary analysis with anticoagulation intensity as a time-varying covariate to ref

SUBMITTER: Halaby R 

PROVIDER: S-EPMC8250316 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature