Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naive Versus Effector CD8⁺ T Cell Transcriptional Programs.

ABSTRACT: Phosphoinositide 3-kinase p110 delta (PI3K p110δ) is pivotal for CD8⁺ T cell immune responses. The current study explores PI3K p110δ induction and repression of antigen receptor and cytokine regulated programs to inform how PI3K p110δ directs CD8⁺ T cell fate. The studies force a revision of the concept that PI3K p110δ controls metabolic pathways in T cells and reveal major differences in PI3K p110δ regulated transcriptional programs between naïve and effector cytotoxic T cells (CTL). These differences include differential control of the expression of cytolytic effector molecules and costimulatory receptors. Key insights from the work include that PI3K p110δ signalling pathways repress expression of the critical inhibitory receptors CTLA4 and SLAMF6 in CTL. Moreover,

SUBMITTER: Spinelli L 

PROVIDER: S-EPMC8250422 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature