Proteomic Dissection of the Impact of Environmental Exposures on Mouse Seminal Vesicle Function.

ABSTRACT: Seminal vesicles are an integral part of the male reproductive accessory gland system. They produce a complex array of secretions containing bioactive constituents that support gamete function and promote reproductive success, with emerging evidence suggesting these secretions are influenced by our environment. Despite their significance, the biology of seminal vesicles remains poorly defined. Here, we complete the first proteomic assessment of mouse seminal vesicles and assess the impact of the reproductive toxicant acrylamide. Mice were administered acrylamide (25 mg/kg bw/day) or control daily for five consecutive days prior to collecting seminal vesicle tissue. A total of 5013 proteins were identified in the seminal vesicle proteome with bioinformatic analyses identifying cell prolifer

SUBMITTER: Skerrett-Byrne DA 

PROVIDER: S-EPMC8250459 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature