Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study.

ABSTRACT:

Background and aims

Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking.

Approach and results

We performed a retrospective study on patients with AIH and COVID-19 from 34 centers in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes, defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity score-matched cohort of patients without AIH but with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase > 2 × the upper limit of normal) during COVID-19 was also evaluated. We included 110 patients with AIH (80% female) with a median age of

SUBMITTER: Efe C 

PROVIDER: S-EPMC8250536 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature