Lupus Anticoagulant Single Positivity During the Acute Phase of COVID-19 Is Not Associated With Venous Thromboembolism or In-Hospital Mortality.

ABSTRACT:

Objective

The clinical relevance of antiphospholipid antibodies (aPLs) in COVID-19 is controversial. This study was undertaken to investigate the prevalence and prognostic value of conventional and nonconventional aPLs in patients with COVID-19.

Methods

This was a multicenter, prospective observational study in a French cohort of patients hospitalized with suspected COVID-19.

Results

Two hundred forty-nine patients were hospitalized with suspected COVID-19, in whom COVID-19 was confirmed in 154 and not confirmed in 95. We found a significant increase in lupus anticoagulant (LAC) positivity among patients with COVID-19 compared to patients without COVID-19 (60.9% versus 23.7%; P < 0.001), while prevalence of conventional aPLs (IgG and IgM anti-β₂ -glycoprote

SUBMITTER: Gendron N 

PROVIDER: S-EPMC8250965 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature