Dataset Information

Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study.

ABSTRACT:

Objective

To determine whether viral coinfection is a risk for severe lower respiratory tract infection (LRTI).

Working hypothesis

Children with viral coinfection had a higher risk for admission to the intensive care unit (ICU) than those with a single virus infection.

Study design

Retrospective, observational study for 10 years.

Patient-subject selection

Children between 1 and 60 months of age hospitalized with LRTI.

SUBMITTER: Eski A

PROVIDER: S-EPMC8250990 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study.

Eşki Aykut A Öztürk Gökçen Kartal GK Çiçek Candan C Gülen Figen F Demir Esen E

Pediatric pulmonology 20210426 7

<h4>Objective</h4>To determine whether viral coinfection is a risk for severe lower respiratory tract infection (LRTI).<h4>Working hypothesis</h4>Children with viral coinfection had a higher risk for admission to the intensive care unit (ICU) than those with a single virus infection.<h4>Study design</h4>Retrospective, observational study for 10 years.<h4>Patient-subject selection</h4>Children between 1 and 60 months of age hospitalized with LRTI. ...[more]

PMID: 33847466

Similar Datasets

Project description:ObjectivesThis study determined associations between respiratory viruses and subsequent illness course in primary care adult patients presenting with acute cough and/or suspected lower respiratory tract infection.MethodsA prospective European primary care study recruited adults with symptoms of lower respiratory tract infection between November 2007 and April 2010. Real-time in-house polymerase chain reaction (PCR) was performed to test for six common respiratory viruses. In this secondary analysis, symptom severity (scored 1 = no problem, 2 = mild, 3 = moderate, 4 = severe) and symptom duration were compared between groups with different viral aetiologies using regression and Cox proportional hazard models, respectively. Additionally, associations between baseline viral load (cycle threshold (Ct) value) and illness course were assessed.ResultsThe PCR tested positive for a common respiratory virus in 1354 of the 2957 (45.8%) included patients. The overall mean symptom score at presentation was 2.09 (95% confidence interval (CI) 2.07-2.11) and the median duration until resolution of moderately bad or severe symptoms was 8.70 days (interquartile range 4.50-11.00). Patients with influenza virus, human metapneumovirus (hMPV), respiratory syncytial virus (RSV), coronavirus (CoV) or rhinovirus had a significantly higher symptom score than patients with no virus isolated (0.07-0.25 points or 2.3-8.3% higher symptom score). Time to symptom resolution was longer in RSV infections (adjusted hazard ratio (AHR) 0.80, 95% CI 0.65-0.96) and hMPV infections (AHR 0.77, 95% CI 0.62-0.94) than in infections with no virus isolated. Overall, baseline viral load was associated with symptom severity (difference 0.11, 95% CI 0.06-0.16 per 10 cycles decrease in Ct value), but not with symptom duration.ConclusionsIn healthy, working adults from the general community presenting at the general practitioner with acute cough and/or suspected lower respiratory tract infection other than influenza impose an illness burden comparable to influenza. Hence, the public health focus for viral respiratory tract infections should be broadened.

Dataset Information

Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study.

Objective

Working hypothesis

Study design

Patient-subject selection

Publications

Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets