Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.

ABSTRACT: Coronavirus Disease 2019 (COVID-19) cases and deaths are still rising worldwide, there is currently no effective treatment for severe inflammation and acute lung injury caused by new coronavirus (SARS-COV-2) infection. Therapies to prevent or treat COVID-19, including antiviral drug and several vaccines, are still being development. Human angiotensin-converting enzyme 2 (ACE2), expressing in lung, has been confirmed to be a receptor for SARS-COV-2 infection, interventions for attachment of spike protein of SARS-CoV-2 to ACE2 may be a potential approach to prevent viral infections and it is considered as a potential target for drug development. In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpressi

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC8251057 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature