Exponential increase in neutralizing and spike specific antibodies following vaccination of COVID-19 convalescent plasma donors.

ABSTRACT:

Background

With the recent approval of COVID-19 vaccines, recovered COVID-19 subjects who are vaccinated may be ideal candidates to donate COVID-19 convalescent plasma (CCP).

Case series

Eleven recovered COVID-19 patients were screened to donate CCP. All had molecularly confirmed COVID-19, and all but one were antibody positive by chemiluminescence immunoassay (DiaSorin) prior to vaccination. All were tested again for antibodies 11-21 days after they were vaccinated (Pfizer/Moderna). All showed dramatic increases (~50-fold) in spike-specific antibody levels and had at least a 20-fold increase in the IC50 neutralizing antibody titer based on plaque reduction neutralization testing (PRNT). The spike-specific antibody levels following vaccination were significantly higher than

SUBMITTER: Vickers MA 

PROVIDER: S-EPMC8251132 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature