Association Between Bone Mineral Density and Autoantibodies in Patients With Rheumatoid Arthritis.

ABSTRACT:

Objective

Autoantibodies, such as anti-citrullinated protein antibodies (ACPAs), have been described as inducing bone loss in rheumatoid arthritis (RA), which can also be reflected by bone mineral density (BMD). We therefore examined the association between osteoporosis and autoantibodies in two independent RA cohorts.

Methods

Dual x-ray absorptiometry (DXA) of the lumbar spine and left hip was performed in 408 Dutch patients with early RA during 5 years of follow-up and in 198 Swedish patients with early RA during 10 years of follow-up. The longitudinal effect of ACPAs and other autoantibodies on several BMD measures was assessed using generalized estimating equations.

Results

In the Dutch cohort, significantly lower BMD at baseline was observed in ACPA-positive pati

SUBMITTER: Amkreutz JAMP 

PROVIDER: S-EPMC8251600 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature