Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines.

ABSTRACT: Renal cell carcinoma (RCC) is not a single disease but is made up of several different histologically defined subtypes that are associated with distinct genetic alterations which require subtype specific management and treatment. Papillary renal cell carcinoma (pRCC) is the second most common subtype after conventional/clear cell RCC (ccRCC), representing ~20% of cases, and is subcategorized into type 1 and type 2 pRCC. It is important for preclinical studies to have cell lines that accurately represent each specific RCC subtype. This study characterizes seven cell lines derived from both primary and metastatic sites of type 1 pRCC, including the first cell line derived from a hereditary papillary renal carcinoma (HPRC)-associated tumor. Complete or partial gain of chromosome 7 was observe

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8251606 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature