Syndecan-3 enhances anabolic bone formation through WNT signaling.

ABSTRACT: Osteoporosis is the most common age-related metabolic bone disorder, which is characterized by low bone mass and deterioration in bone architecture, with a propensity to fragility fractures. The best treatment for osteoporosis relies on stimulation of osteoblasts to form new bone and restore bone structure, however, anabolic therapeutics are few and their use is time restricted. Here, we report that Syndecan-3 increases new bone formation through enhancement of WNT signaling in osteoblasts. Young adult Sdc3^-/- mice have low bone volume, reduced bone formation, increased bone marrow adipose tissue, increased bone fragility, and a blunted anabolic bone formation response to mechanical loading. This premature osteoporosis-like phenotype of Sdc3^-/- mice is due to delayed

SUBMITTER: Johnson de Sousa Brito FM 

PROVIDER: S-EPMC8251628 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature