Mannose-6-phosphate complex and improvement in biomechanical properties of the skin.

ABSTRACT:

Background

The dermis is composed of a tangle of macromolecules that provides the skin its biomechanical properties. During chronological aging, fibroblasts lose their ability to synthesize collagen and an accumulation of matrix metalloproteinases leads to an increase in collagen degradation. As a result, there is a decline in the biomechanical properties of the skin. Skin aging is accelerated by external factors such as UV radiation and pollution, which induce accumulation of oxidants, and so of oxidized proteins in the skin.

Aims

Atomic force microscopy (AFM) has emerged as an alternative method for studying the biomechanical properties of skin cells and tissues.

Methods/results

Thus, we identified mannose-6-phosphate complex as a new powerful molecule capable of re

SUBMITTER: Meunier M 

PROVIDER: S-EPMC8251629 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature