Light-Driven gem Hydrogenation: An Orthogonal Entry into "Second-Generation" Ruthenium Carbene Catalysts for Olefin Metathesis.

ABSTRACT: The newly discovered light-driven gem hydrogenation of alkynes opens an unconventional yet efficient entry into five-coordinate Grubbs-type ruthenium carbene complexes with cis-disposed chloride ligands. Representatives of this class featuring a chelate substructure formed by an iodo-substituted benzylidene unit react with (substituted) 2-isopropoxystyrene to give prototypical "second-generation" Grubbs-Hoveyda complexes for olefin metathesis. The new approach to this venerable catalyst family is safe and versatile as it uses a triple bond rather than phenyldiazomethane as the ultimate carbene source and does not require any sacrificial phosphines.

SUBMITTER: Zachmann RJ 

PROVIDER: S-EPMC8251631 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature