Control yourself: ISPE-endorsed guidance in the application of self-controlled study designs in pharmacoepidemiology.

ABSTRACT:

Purpose

Consensus is needed on conceptual foundations, terminology and relationships among the various self-controlled "trigger" study designs that control for time-invariant confounding factors and target the association between transient exposures (potential triggers) and abrupt outcomes. The International Society for Pharmacoepidemiology (ISPE) funded a working group of ISPE members to develop guidance material for the application and reporting of self-controlled study designs, similar to Standards of Reporting Observational Epidemiology (STROBE). This first paper focuses on navigation between the types of self-controlled designs to permit a foundational understanding with guiding principles.

Methods

We leveraged a systematic review of applications of these designs, that

SUBMITTER: Cadarette SM 

PROVIDER: S-EPMC8251635 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature