A Cytotoxic Bis(1,2,3-triazol-5-ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation.

ABSTRACT: The syntheses of bis(triazolium)carbazole precursors and their corresponding coinage metal (Au, Ag) complexes are reported. For alkylated triazolium salts, di- or tetranuclear complexes with bridging ligands were isolated, while the bis(aryl) analogue afforded a bis(carbene) Au^I -CNC pincer complex suitable for oxidation to the redox-stable [Au^III (CNC)Cl]⁺ cation. Although the ligand salt and the [Au^III (CNC)Cl]⁺ complex were both notably cytotoxic toward the breast cancer cell line MDA-MB-231, the Au^III complex was somewhat more selective. Electrophoresis, viscometry, UV-vis, CD and LD spectroscopy suggest the cytotoxic [Au^III (CNC)Cl]⁺ complex behaves as a partial DNA intercalator. In silico screenin

SUBMITTER: van der Westhuizen D 

PROVIDER: S-EPMC8251726 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature