Three-dimensional gradient and spin-echo readout for time-encoded pseudo-continuous arterial spin labeling: Influence of segmentation factor and flow compensation.

ABSTRACT:

Purpose

To monitor the complete passage of the labeled blood through the vascular tree into tissue and improve the quantification of ASL maps, we evaluated the effect of 3D gradient and spin-echo (GRASE) readout segments on temporal SNR (tSNR) and image blurriness for time-encoded pseudo-continuous arterial spin labeling and the effect of flow-compensation gradients on the presence of intravascular signal.

Methods

Fifteen volunteers were scanned using time-encoded pCASL with 2D EPI and single-segment, two-segments, and three-segments 3D-GRASE readouts with first-order flow compensation (FC) gradients. Two-segments 3D-GRASE scans were acquired with 25%, 50%, 75%, and 100% of full first-order FC. Temporal SNR was assessed, and cerebral blood flow and arterial blood volume were

SUBMITTER: Paschoal AM 

PROVIDER: S-EPMC8251744 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature