ParaHydrogen Polarized Ethyl-[1-¹³ C]pyruvate in Water, a Key Substrate for Fostering the PHIP-SAH Approach to Metabolic Imaging.

ABSTRACT: An efficient synthesis of vinyl-[1-¹³ C]pyruvate has been reported, from which ¹³ C hyperpolarized (HP) ethyl-[1-¹³ C]pyruvate has been obtained by means of ParaHydrogen Induced Polarization (PHIP). Due to the intrinsic lability of pyruvate, which leads quickly to degradation of the reaction mixture even under mild reaction conditions, the vinyl-ester has been synthesized through the intermediacy of a more stable ketal derivative. ¹³ C and ¹ H hyperpolarizations of ethyl-[1-¹³ C]pyruvate, hydrogenated using ParaHydrogen, have been compared to those observed on the more widely used allyl-derivative. It has been demonstrated that the spin order transfer from ParaHydrogen protons to ¹³ C, is more efficient on the eth

SUBMITTER: Carrera C 

PROVIDER: S-EPMC8251755 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature