Titanocene-Catalyzed [2+2] Cycloaddition of Bisenones and Comparison with Photoredox Catalysis and Established Methods.

ABSTRACT: Cp₂ Ti(TFA) is a broadly applicable catalyst for the [2+2] cycloaddition of bisenones by inner-sphere electron transfer. The attractiveness of this mechanism is shown by comparison with outer-sphere ET methods. DFT calculations show that the reaction proceeds through a unique unfavorable 5-exo (the rate-determining step) and a favorable 4-exo cyclization.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8251790 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature