Diversifying Metal-Ligand Cooperative Catalysis in Semi-Synthetic [Mn]-Hydrogenases.

ABSTRACT: The reconstitution of [Mn]-hydrogenases using a series of Mn^I complexes is described. These complexes are designed to have an internal base or pro-base that may participate in metal-ligand cooperative catalysis or have no internal base or pro-base. Only Mn^I complexes with an internal base or pro-base are active for H₂ activation; only [Mn]-hydrogenases incorporating such complexes are active for hydrogenase reactions. These results confirm the essential role of metal-ligand cooperation for H₂ activation by the Mn^I complexes alone and by [Mn]-hydrogenases. Owing to the nature and position of the internal base or pro-base, the mode of metal-ligand cooperation in two active [Mn]-hydrogenases is different from that of the native [Fe]-hydro

SUBMITTER: Pan HJ 

PROVIDER: S-EPMC8251902 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature