Ontology highlight
ABSTRACT:
SUBMITTER: Street STG
PROVIDER: S-EPMC8251916 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Street Steven T G STG Peñalver Pablo P O'Hagan Michael P MP Hollingworth Gregory J GJ Morales Juan C JC Galan M Carmen MC
Chemistry (Weinheim an der Bergstrasse, Germany) 20210502 28
A facile imide coupling strategy for the one-step preparation of G-quadruplex ligands with varied core chemistries is described. The G-quadruplex stabilization of a library of nine compounds was examined using FRET melting experiments, and CD, UV-Vis, fluorescence and NMR titrations, identifying several compounds that were capable of stabilizing G-quadruplex DNA with interesting selectivity profiles. The best G4 ligand was identified as compound 3, which was based on a perylene scaffold and exhi ...[more]