Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis.

ABSTRACT:

Objective

Many multiple sclerosis (MS) genetic susceptibility variants have been identified, but understanding disease heterogeneity remains a key challenge. Relapses are a core feature of MS and a common primary outcome of clinical trials, with prevention of relapses benefiting patients immediately and potentially limiting long-term disability accrual. We aim to identify genetic variation associated with relapse hazard in MS by analyzing the largest study population to date.

Methods

We performed a genomewide association study (GWAS) in a discovery cohort and investigated the genomewide significant variants in a replication cohort. Combining both cohorts, we captured a total of 2,231 relapses occurring before the start of any immunomodulatory treatment in 991 patients. For a

SUBMITTER: Vandebergh M 

PROVIDER: S-EPMC8252032 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature