Quantifying pulmonary perfusion from noncontrast computed tomography.

ABSTRACT:

Purpose

Computed tomography (CT)-derived ventilation methods compute respiratory induced volume changes as a surrogate for pulmonary ventilation. Currently, there are no known methods to derive perfusion information from noncontrast CT. We introduce a novel CT-Perfusion (CT-P) method for computing the magnitude mass changes apparent on dynamic noncontrast CT as a surrogate for pulmonary perfusion.

Methods

CT-Perfusion is based on a mass conservation model which describes the unknown mass change as a linear combination of spatially corresponding inhale and exhale HU estimated voxel densities. CT-P requires a deformable image registration (DIR) between the inhale/exhale lung CT pair, a preprocessing lung volume segmentation, and an estimate for the Jacobian of the DIR transfor

SUBMITTER: Castillo E 

PROVIDER: S-EPMC8252085 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature