Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy.

ABSTRACT: Insulin resistance is a major contributor to the neuroplasticity deficits observed in patients with metabolic disorders. However, the relative contribution of peripheral versus central insulin resistance in the development of neuroplasticity deficits remains equivocal. To distinguish between peripheral and central insulin resistance, we developed a lentiviral vector containing an antisense sequence selective for the insulin receptor (LV-IRAS). We previously demonstrated that intra-hippocampal injection of this vector impairs synaptic transmission and hippocampal-dependent learning and memory in the absence of peripheral insulin resistance. In view of the increased risk for the development of neuropsychiatric disorders in patients with insulin resistance, the current study examined depressi

SUBMITTER: Reagan LP 

PROVIDER: S-EPMC8252121 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature