Bayesian evidence synthesis to estimate subnational TB incidence: An application in Brazil.

ABSTRACT:

Background

Evidence on local disease burden and the completeness of case detection represent important information for TB control programs. We present a new method for estimating subnational TB incidence and the fraction of individuals with incident TB who are diagnosed and treated in Brazil.

Methods

We compiled data on TB notifications and TB-related mortality in Brazil and specified an analytic model approximating incidence as the number of individuals exiting untreated active disease (sum of treatment initiation, death before treatment, and self-cure). We employed a Bayesian inference approach to synthesize data and adjust for known sources of bias. We estimated TB incidence and the fraction of cases treated, for each Brazilian state and the Federal District over 2008-201

SUBMITTER: Chitwood MH 

PROVIDER: S-EPMC8252152 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature