Innovative trial approaches in immune-mediated inflammatory diseases: current use and future potential.

ABSTRACT:

Background

Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest form of evidence on the effectiveness of a potential new treatment regimen, but they are extremely expensive and time consuming to conduct. Consequently, much focus has been given in recent years to innovative design and analysis methods that could improve the efficiency of RCTs. In this article, we review the current use and future potential of these methods within the context of IMID trials.

Methods

We provide a review of several innovative methods that would provide utility in IMID research. These include novel study designs (adaptive trials, Sequential M

SUBMITTER: Grayling MJ 

PROVIDER: S-EPMC8252241 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature