Abnormally increased DNA methylation in chorionic tissue might play an important role in development of ectopic pregnancy.

ABSTRACT:

Background

Human Ectopic Pregnancy (hEP) is the second most common cause of pregnancy-related deaths in the first trimester. Without timely detection, EPs can lead to an increased rate of infertility and an elevated risk for future tubal EPs. In addition, most studies in the field focus on the effect of the fallopian tube (maternal factors) and ignore epigenetic changes in genes and proteins of the embryo, which may also cause EPs. Therefore, the present study hypothesized that embryos also play an important role in the development of EP. The study also speculated that DNA methylation is associated with ectopic pregnancy. Consequently, the effects of DNA methylation on the occurrence and development of ectopic pregnancy were investigated. Moreover, genome-wide DNA methylation of ch

SUBMITTER: Cai W 

PROVIDER: S-EPMC8252306 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature