Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation.

ABSTRACT:

Background

The relationship between psoriasis and hepatitis C was previously controversial, so our purpose is to investigate this connection.

Methods

We conducted a systematic review of the case-control, cross-sectional and cohort studies examining the association between psoriasis and hepatitis C in PubMed, EMBASE and Cochrane library databases and investigated the overlapping genes between psoriasis targets and hepatitis C targets using bioinformatics analysis. Based on overlapping genes and hub nodes, we also constructed the protein-protein interaction (PPI) network and module respectively, followed by the pathway enrichment analysis.

Results

We included 11 publications that reported a total of 11 studies (8 cross-sectional and 3 case-control). The case-control and

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8252322 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature