An Octa-Urea [Pd₂ L₄ ]⁴⁺ Cage that Selectively Binds to n-octyl-α-D-Mannoside.

ABSTRACT: Designing compounds for the selective molecular recognition of carbohydrates is a challenging task for supramolecular chemists. Macrocyclic compounds that incorporate isophtalamide or bisurea spacers linking two aromatic moieties have proven effective for the selective recognition of all-equatorial carbohydrates. Here, we explore the molecular recognition properties of an octa-urea [Pd₂ L₄ ]⁴⁺ cage complex (4). It was found that small anions like NO₃^- and BF₄^- bind inside 4 and inhibit binding of n-octyl glycosides. When the large non-coordinating anion 'BAr^F ' was used, 4 showed excellent selectivity towards n-octyl-α-D-Mannoside with binding in the order of K_a ≈16 M^-1 versus non-

SUBMITTER: Schaapkens X 

PROVIDER: S-EPMC8252426 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature