Sex-based differences in fecal short-chain fatty acid and gut microbiota in irritable bowel syndrome patients.

ABSTRACT:

Objective

To explore alterations in fecal short-chain fatty acids (SCFA) and gut microbiota in patients with diarrhea-predominant irritable bowel disease (IBS-D) and their relationships with clinical manifestations.

Methods

We recruited 162 patients with IBS-D and 66 healthy controls (HC). Their manifestations and psychological status were evaluated using the IBS severity scoring system and the Hospital Anxiety and Depression Scale (HADS). Colorectal visceral sensitivity was evaluated using a barostat. Systemic inflammation was evaluated using plasma cytokine levels. Fecal SCFA were quantified using ultra-performance liquid chromatography-tandem mass spectrometry, and fecal microbiota communities were analyzed using 16S rRNA sequencing.

Results

More men presented with

SUBMITTER: Sun QH 

PROVIDER: S-EPMC8252430 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature