Enantioselective Copper-Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones.

ABSTRACT: Quinazolinones are common substructures in molecules of medicinal importance. We report an enantioselective copper-catalyzed borylative cyclization for the assembly of privileged pyrroloquinazolinone motifs. The reaction proceeds with high enantio- and diastereocontrol, and can deliver products containing quaternary stereocenters. The utility of the products is demonstrated through further manipulations.

SUBMITTER: Dherbassy Q 

PROVIDER: S-EPMC8252434 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature