The effect of 5-HT_1A receptor agonists on the entopeduncular nucleus is modified in 6-hydroxydopamine-lesioned rats.

ABSTRACT:

Background and purpose

l-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT_1A receptors. Since the internal segment of the globus pallidus, homologous to the entopeduncular nucleus in rodents, seems to be involved in the etiopathology of l-DOPA-induced dyskinesia, we investigated whether the entopeduncular nucleus is modulated by the 5-HT_1A receptor partial and full agonists, buspirone, and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) in control and 6-hydroxydopamine (6-OHDA)-lesioned rats with or without long-term l-DOPA treatment.

Experimental approach

Extracellular single-unit electrocorticogram and local field potential recordings under anaesthesia, immunostaining assa

SUBMITTER: Vegas-Suarez S 

PROVIDER: S-EPMC8252460 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature